Est-Adapt is an estriol-only formulation, maximizing dosing options. Est-Adapt contains 0.5 mg per drop of estriol while competing products contain only 0.2 mg per drop. Other brands combine estriol and progesterone in the same formula, negating the opportunity for precision dosing. This creates limitations for addressing clinical needs and eliminates the option to use estriol on its own. Est-Adapt, containing only bioidentical estriol, enables personalized dosing of estrogen based on your individual needs.

Estriol is naturally produced in the body. Along with progesterone, estrogen is created in the ovaries and is needed to support a woman’s reproductive health. Research shows that estriol helps support the urinary tract. BioMatrix estriol is derived from an extraction of the steroidal backbone of the Mexican Wild Yam (Dioscorea villosa). It is bioidentical, meaning it has the same molecular structure as that produced naturally by the body.

Vitamin E (mixed with tocopherols) is a blend of natural-source alpha-tocopherol and mixed tocopherols. An independent assay of a leading brand of oil-based hormones determined that only one form of vitamin E (tocopheryl acetate) is included in their formula. Acetate is cheap acid, used in wood glue. BioMatrix Est-Adapt uses premium vitamin E in mixed tocopherol forms for enhanced stability and oxidative protection.

Rice Bran Oil is a reliable oil carrier that contributes to the stability and viscosity of numerous formulas.

What Est-Adapt does:

  • Provides bioidentical estriol
  • Eases symptoms associated with a deficiency or imbalance of estrogen, such as hot flashes, night sweats, dryness, and brain fog

Nutrition & Ingredients:

Per drop (approx. 500 drops per bottle):

0.5mg of USP Estriol (topical oil)

Other ingredients: Rice Bran Oil‚ Vitamin E (with mixed tocopherols)


SHAKE WELL, then apply 2 to 8 drops. Repeat procedure twice daily, or as directed by your healthcare practitioner. For optimal use, shake the bottle well then clear the dropper three or four times prior to each use. 

Bottle is 1/3 full by design! This allows for optimal dispersion of the formula when shaking.

Store at room temperature.

Cautions / Contraindications:

Always consult with your healthcare practitioner before use.


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